Amyloidosis Disease

Amyloid is a filiform glycoprotein, that is, protein-carbohydrate compound derived from immunoglobulins, and when it accumulates in organs and tissues in the body, it disrupts their normal functions. Amyloidosis is a rare and serious disease that occurs due to the accumulation of amyloid in the connective tissue.

Aim in the RTM system is not to remove amyloid deposition by supressing directly but to reveal the causes that cause amyloid accumulation specific to the individual and to determine the source part of the disease. In the treatment, it is aimed to prevent the negative course by correcting the infrastructure that causes amyloid production and accumulation.

Let’s glance shortly at Amyloidosis Disease…

What is Amyloidosis Disease?

Amyloidosis is a rare disease that causes dysfunction in organs with the accumulation of a fibrillar protein structure in organs and tissues. It is necessary to approach amyloidosis not as a single disease, but as a group of diseases that have similar biochemical properties but are formed by the deposition of different protein types.

What are the Types of Amyloidosis?

Amyloidosis can be divided into primary and secondary. Spontaneous amyloidosis, not related to another disease, is called primary amyloidosis. If the disease is not primary but develops after another disease, it is considered as secondary amyloidosis.

It is also divided into two groups as localized or systemic. Localized amyloidosis is located in only one part of the body, while systemic amyloidosis is a type of amyloidosis that affects multiple organs in the body.

There are more than 20 different types of described amyloidosis. Some of them are listed below.

AL amyloidosis: It is the most common type of amyloidosis, previously called primary amyloidosis. It happens when the bone marrow produces abnormal antibodies.

AA amyloidosis: This type, formerly called secondary amyloidosis, is seen as a result of another disease such as ulcerative colitis, rheumatoidarthritis, Crohn’s disease. It can affect mainly the kidneys, as well as the heart, lungs and digestive system.

Dialysis-associated amyloidosis (DRA): It is common in people who have been on dialysis for more than 5 years. It mostly affects the tendons, bones and joints.

Familial or hereditary amyloidosis: It is a rare form inherited. Many genetic defects are linked to a higher risk of amyloid disease.

Age-related (senile) systemic amyloidosis: It is a type that is more common in older men. It is due to normal accumulation of TTR in the heart and other tissues.

Organ-specific amyloidosis: It causes accumulation of amyloid protein in a single organ. For example, its accumulation in the brain can cause Alzheimer’s disease.

 What Causes Amyloidosis?

Amyloidosis can develop due to different reasons, the main reasons can be listed as follows.

Some types are inherited depending on family history.

Although it is rarely seen in modern dialysis techniques, large proteins that need to be removed from the blood but not removed by dialysis may remain in dialysis patients and these proteins may accumulate in the tissue.

 It can occur with advancing age, especially between the ages of 60 and 70, and is more common in men.

Having an infectious disease, chronic diseases or an inflammatory disease can increase the risk of amyloidosis.

 What are the Symptoms of Amyloidosis Disease?

In amyloidosis, quite different symptoms may appear, depending on the site of the disease, and most people do not experience symptoms until the disease is well advanced.

Symptoms vary according to the organs affected by the disease, but in general they can be listed as follows:

  • Changes in the skin; discoloration, thickening of the skin, increased sensitivity, easy injury and bruises in the eye area
  • Extreme fatigue, weakness
  • Joint pains
  • Anemia
  • Difficulty in breathing
  • Swelling of the tongue due to edema and difficulty in swallowing
  • Tingling, numbness and pain in hands, feet, legs and arms
  • Pain with swelling, especially in the wrists
  • Diarrhea (bloody) or constipation
  • Sudden weight loss
  • Feeling of fullness faster than expected during the meal
  • Irregularity in heart rhythm

Who Gets Amyloidosis Disease?

Primeramyloidosis: It is more common in patients over 40 years of age, in diseases involving the bone marrow, and in men.

Secondary amyloidosis: It is more common in men over 40 years of age, in rheumatic and chronic inflammatory diseases, and in men.

How to Diagnose Amyloidosis Disease?

It is very important to take a detailed medical history along with a comprehensive physical examination.

Detailed blood and urine tests are done. If necessary, tissue samples can be taken from fat, marrow or other areas for biopsy. Imaging methods can also aid diagnosis. He or she may do a genetic test if it’s considered an inherited strain.

Approach to Amyloidosis Disease in the RTM System

An Outlook on the Cause of Amyloidosis in the RTM System

Our body is in a constant balance against internal and external factors. With this balance, life continues by progressing. The RTM System includes its own diagnostic and treatment protocols. Diseases in the RTM System; It is seen as a new balance or new adjustment points created in the body in order to continue life against internal and external negative conditions.

There is a source pattern called the Triad of Disease, which causes new settings to come into play in the body. This triple structure, which includes contamination in the body, system disorders and code changes in DNA (epigenetics), functions as follows in Amyloidosis;

Contamination in the Body:

When the metabolic wastes and toxins released in the body as a result of aging or chronic diseases such as autoimmune diseases that increase the inflammatory process in the body, they begin to accumulate in the connective tissue or various organs when the detoxifying organs exceed their cleaning capacity.

Deterioration in Systems:

As a result of insufficiency in the circulatory system, chronic diseases, chronic diseases involving the detox organs (liver, lung, skin, kidney), there will be a reversible accumulation of metabolic wastes that will make it difficult to clean the body.

As a result of contamination in the body or deterioration of systems, the body will take new decisions regarding detox processes. Removal of the metabolic wastes from the body will take longer time. This change will be encoded in the body at the information level, and eventually a code change (Epigenetic change) will occur in the DNA. This change in the information form will be in the form of amyloidosis accumulations in the processes when the problem arises. The result of this new set point determined by the body is Amyloidosis.

Treatment of Amyloidosis in the RTM System

The purpose of the RTM System is not to directly suppress the symptoms of Amyloidosis, but to make away with the Triad of Disease, which is the source of the disease, as we mentioned above. In the RTM System, this is called the Treatment Triad.

Treatment Triat includes processes aimed at initiating the detox process to return to the normal state of balance in the body, eliminating the imbalance in the failing systems and reversing the epigenetic changes in DNA. This process is planned completely individually.

The main backbone of the treatment triad is RTM Phytotherapy. The phytotherapy protocol is determined by evaluating the detailed anamnesis, laboratory and imaging findings of the individual, and measurements specific to RTM clinics. With the RTM Phytotherapy protocol, the disease triad, which constitutes the source part, is withdrawn and treatment is applied.

It is aimed to normalize the epigenetic changes in DNA, which determine the new tuning constants, by informing the body with the seed parts of the plants. In order for the body to adapt to the normalization of this information, the treatment triad is activated by using the leafy parts of the plants, accelerating the detox activities in the body and regulating the systems. When the disease triad is withdrawn, it is aimed that the body will by itself return to the norm form.

In order to both support the body and accelerate the treatment process, in addition to RTM phytotherapeutics, nearly 25 traditional medicine methods such as Ozone, Cupping, Acupuncture, Magnetic field therapy are planned according to the needs of the patient.

Frequently Asked Questions

What does amyloid accumulation in the kidney mean, what problems can it cause?

Amyloid protein accumulating in the kidney leads to renal amyloidosis, loss of protein in the urine with impaired filtering ability of the kidneys, and subsequently the development of renal failure.

What is Kidney Amyloidosis?

The accumulation of proteins called amyloid in the kidney is called Kidney Amyloidosis.

What is amyloidosis FMF?

FMF means Familial Mediterranean Fever. It is an inherited disease with inflammatory, febrile and painful attacks triggered by the body itself due to genetic reasons.

Amyloidosis associated with FMF can cause damage to organs by causing the protein to accumulate outside the tissues. It is most often diagnosed in childhood, and the symptoms can last a lifetime.

Early diagnosis and initiation of treatment of Familial Mediterranean Fever, which is a frequently encountered disease in our country, is very important in terms of preventing possible harms and vital risks.

Why does Serum Amyloid A (SAA) rise?

SAA is the deposition of Amyloid A fibrils in different organs. Like CRP, measurement of SAA is also functional in the diagnosis of inflammatory disease and in the follow-up of the disease and its treatment. Measurement of CRP and SAA together is important in providing diagnostic benefit.

Is amyloidosis disease fatal?

It is not fatal if treated timely and correctly. Otherwise, depending on the type, a life-threatening risk may occur.